Cyclopamine Compound FrameworkCyclopamine
Cyclopamine is actually a specific Hedgehog (Hh) signaling pathway antagonist of Smoothened (Smo) with IC50 of 46 nM in TM3Hh12 muscle.
Examination show off: Being open to cyclopamine endorses pancreatic enlargement in embryonic girls. (Kim SK, et,al. PNAS, 1998, 95: 13036-13041.)
This piece of equipment can be found in : Bioactive Ingredient Assortment, Natural and organic Substance Series
TWS119 Ingredient ConstructionTWS119
TWS119 is truly a GSK-3β inhibitor with IC50 of 30 nM inside a cellular-free of charge assay equipped at inducing neuronal differentiation and could show beneficial to arrive cell phone biology.
Examine emphasize: TWS119, a 4,6-disubstituted pyrrolopyrimidine that can induce neurogenesis in murine ESCs. (Ding S, et,al. PNAS, 2003，100(13): 7632-7637. )
This device consists of in : Bioactive Compound Assortment
Nicotinamide Product or service Developing Nicotinamide
Nicotinamide (Nutritional health supplement nutritional supplement B3), a drinking water-soluble nutritional supplement, is surely an energetic part of coenzymes NAD and NADP, along with respond as an activator of sirtuins.
Research focus on: nicotinamide increased the provide of differentiation of Embryonic Originate Tissues to pancreatic endocrine tissue (Lumelsky N,et,al.Science, 2001, 292(5520): 1389-1394 )
This system entails in : Approved Drug Library, All-normal Component Assortment
Checking libraries to distinguish a lot more functionally special small substances!
Requires 3071 moderate molecule materials
An authentic variety of 1700 accepted medications
Attributes 640 organic and all-natural substances
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